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KMID : 0892920090180010062
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Experimental Neurobiology
2009 Volume.18 No. 1 p.62 ~ p.65
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Sustained Expression of Neuritin mRNA After Repeated Electroconvulsive Stimulations in the Rat Hippocampal Formation
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Park Kun-Woo
Kim Il-Hwan
Sun Woong
Kim Hyun
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Abstract
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In the present study, we compared the expression patterns of neuritin mRNA in the dentate gyrus of hippocampal formation following single (1×ECS) or repeated elctroconvulsive seizures (8×ECS) treatments to the rat. The expression of neuritin mRNA was transiently increased, and returned to basal level within 12 hours after 1×ECS. Whereas initial induction of neuritin mRNA was similarly seen, these increased mRNA level was maintained for 24 hours in 8×ECS group. In contrast, induction profile of BDNF was similar following 1× and 8×ECS. These results suggest that regulation of neuritin expression may be plastically changed by repeated ECS treatment.
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KEYWORD
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neuritin, elctroconvulsive seizure (ECS), neuronal plasticity, dentate gyrus
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